Get access

A New Approach for an Organocatalytic Multicomponent Domino Asymmetric Reaction

Authors

  • Armando Carlone,

    1. Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
    Search for more papers by this author
  • Silvia Cabrera Dr.,

    1. Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
    Search for more papers by this author
  • Mauro Marigo Dr.,

    1. Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
    Search for more papers by this author
  • Karl Anker Jørgensen Prof. Dr.

    1. Danish National Research Foundation, Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark, Fax: (+45) 8919-6199
    Search for more papers by this author

  • This work was made possible by a grant from the Danish National Research Foundation. Thanks are expressed to Dr. Jacob Overgaard for performing X-ray analysis.

Abstract

original image

As easy as pouring! Three C[BOND]C bonds, up to three stereocenters, and ee values greater than 97 % are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS=trimethylsilyl; EWG=electron-withdrawing group). Very high enantioselectivity, control of the substituents, easy handling, and user-friendly reaction conditions are key features of this transformation.

Ancillary