Communication

Xerogel-Encapsulated W110A Secondary Alcohol Dehydrogenase from Thermoanaerobacter ethanolicus Performs Asymmetric Reduction of Hydrophobic Ketones in Organic Solvents†

  1. Musa M. Musa1,2,
  2. Karla I. Ziegelmann-Fjeld3,
  3. Claire Vieille Dr.3,
  4. J. Gregory Zeikus Prof.3,
  5. Robert S. Phillips Prof.1,2

Article first published online: 16 MAR 2007

DOI: 10.1002/anie.200604615

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 46, Issue 17, pages 3091–3094, April 20, 2007

Additional Information

How to Cite

Musa, Musa M., Ziegelmann-Fjeld, Karla I., Vieille, C., Zeikus, J. Gregory. and Phillips, Robert S. (2007), Xerogel-Encapsulated W110A Secondary Alcohol Dehydrogenase from Thermoanaerobacter ethanolicus Performs Asymmetric Reduction of Hydrophobic Ketones in Organic Solvents. Angew. Chem. Int. Ed., 46: 3091–3094. doi: 10.1002/anie.200604615

Author Information

  1. 1

    Department of Chemistry, University of Georgia, 1001 Cedar St., Athens, GA 30602, USA

  2. 2

    Department of Biochemistry and Molecular Biology, University of Georgia, B122 Life Sciences Building, Athens, GA 30602, USA, Fax: (+1) 706-542-9454

  3. 3

    Department of Biochemistry and Molecular Biology, Michigan State University, 410 Biochemistry Building, East Lansing, MI 48824, USA

  1. †

    We gratefully acknowledge financial support from the National Science Foundation (grant no. 0445511) to R.S.P., J.G.Z., and C.V.

Publication History

  1. Issue published online: 12 APR 2007
  2. Article first published online: 16 MAR 2007
  3. Manuscript Revised: 26 JAN 2007
  4. Manuscript Received: 13 NOV 2006

Funded by

  • National Science Foundation. Grant Number: 0445511

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Keywords:

  • asymmetric catalysis;
  • enantioselectivity;
  • enzymes;
  • oxidoreductases;
  • sol–gel processes
Thumbnail image of graphical abstract

To gel well: The asymmetric reduction of hydrophobic ketones by xerogel-immobilized W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus (TeSADH) in organic solvents affords their S-configured alcohols in yields comparable with those achieved by using the free enzyme, and, in some cases, with higher enantioselectivities. R=phenyl-ring-containing substituent.

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