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Reversible Sugar Transfer by Glycosyltransferases as a Tool for Natural Product (Bio)synthesis


  • The authors are grateful to the DFG and the BMBF for supporting their research and to the unknown reviewers for helpful comments regarding this manuscript.


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A bit of give and take: The recently described reversibility of sugar transfer by glycosyltransferases allows the exchange of sugar or aglycon moieties resulting in the formation of novel glycosylated compounds in a one-pot reaction (see picture; NDP=nucleoside diphosphate, GT=glycosyltransferase).