Communication

Bioceramic Macrocapsules for Cell Immunoisolation†

  1. Shaomin Liu Dr.1,
  2. Lihong Liu Dr.2,
  3. Zhi Ping Xu Dr.1,
  4. Aimin Yu Dr.1,
  5. Gao Qing Lu Prof.1,
  6. Joao C. Diniz da Costa Dr.1

Article first published online: 16 MAR 2007

DOI: 10.1002/anie.200604682

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 46, Issue 17, pages 3062–3065, April 20, 2007

Additional Information

How to Cite

Liu, S., Liu, L., Xu, Z., Yu, A., Lu, G. and Diniz da Costa, J. (2007), Bioceramic Macrocapsules for Cell Immunoisolation. Angewandte Chemie International Edition, 46: 3062–3065. doi: 10.1002/anie.200604682

Author Information

  1. 1

    ARC Centre for Functional Nanomaterials, School of Engineering and Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Queensland 4072, Australia, Fax: (+61) 733-656-074

  2. 2

    Institute of Bioengineering and Nanotechnology, 31 Biopolis, The Nanos, Singapore 138669, Singapore

  1. †

    The authors acknowledge the financial support from the ARC Centre for Functional Nanomaterials funded by the Australia Research Council under its Centre of Excellence Scheme. The authors wish to express sincere gratitude to Dr. Peilin Mao, Yuanhong Yu, and Dr. Xigeng Miao for their valuable suggestions and assistance.

Publication History

  1. Issue published online: 12 APR 2007
  2. Article first published online: 16 MAR 2007
  3. Manuscript Revised: 17 JAN 2007
  4. Manuscript Received: 17 NOV 2006

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Keywords:

  • ceramics;
  • gene technology;
  • immunoisolation;
  • protein permeation;
  • zirconia

Graphical Abstract

Thumbnail image of graphical abstract

A bone to pick: Tailor-made zirconia macrocapsules are biocompatible and friendly to MC3T3-E1 cells and can facilitate osteoblast cell differentiation. Cells encapsulated within such capsular chambers are viable and grow well by absorbing the nutrients permeated through the capsule micropores from the outside environment. These capsules are promising as immunoisolation medical templates for bone-tissue engineering.

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