We acknowledge financial support from NIH (U54-CA119343 and P20 RR020764). We thank Ms. Kathy Wilber for experimental help. W.J.R. thanks NSF for a graduate fellowship and W.L. is a Camille Dreyfus Teacher–Scholar.
Hybrid Silica Nanoparticles for Multimodal Imaging†
Article first published online: 5 APR 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 20, pages 3680–3682, May 11, 2007
How to Cite
Rieter, William J., Kim, Jason S., Taylor, Kathryn M. L., An, H., Lin, W., Tarrant, T. and Lin, W. (2007), Hybrid Silica Nanoparticles for Multimodal Imaging. Angew. Chem. Int. Ed., 46: 3680–3682. doi: 10.1002/anie.200604738
- Issue published online: 4 MAY 2007
- Article first published online: 5 APR 2007
- Manuscript Received: 21 NOV 2006
- NIH. Grant Numbers: U54-CA119343, P20 RR020764
- imaging agents;
- magnetic resonance imaging;
Lighting things up: Multifunctional silica nanoparticles containing a luminescent core and a paramagnetic coat are prepared, and their utility as multimodal imaging probes is demonstrated in vitro. Monocyte cells can be labeled with the hybrid nanoparticles with greater than 98 % efficiency and do not experience measurable toxicity even at a high loading of 0.123 mg per 5000 cells.