Hybrid Silica Nanoparticles for Multimodal Imaging


  • We acknowledge financial support from NIH (U54-CA119343 and P20 RR020764). We thank Ms. Kathy Wilber for experimental help. W.J.R. thanks NSF for a graduate fellowship and W.L. is a Camille Dreyfus Teacher–Scholar.


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Lighting things up: Multifunctional silica nanoparticles containing a luminescent core and a paramagnetic coat are prepared, and their utility as multimodal imaging probes is demonstrated in vitro. Monocyte cells can be labeled with the hybrid nanoparticles with greater than 98 % efficiency and do not experience measurable toxicity even at a high loading of 0.123 mg per 5000 cells.