This research was supported by the NSF-supported Materials Research Science & Engineering Center. The authors thank Wei-Jen Tang for providing engineered CaM plasmids and Young-Sam Lee for technical assistance.
Dynamic Hydrogels: Translating a Protein Conformational Change into Macroscopic Motion†
Article first published online: 15 MAR 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 17, pages 3066–3069, April 20, 2007
How to Cite
Murphy, William L., Dillmore, W. Shannon., Modica, J. and Mrksich, M. (2007), Dynamic Hydrogels: Translating a Protein Conformational Change into Macroscopic Motion. Angew. Chem. Int. Ed., 46: 3066–3069. doi: 10.1002/anie.200604808
- Issue published online: 12 APR 2007
- Article first published online: 15 MAR 2007
- Manuscript Received: 27 NOV 2006
- supramolecular chemistry
Natural inspiration: A bioinspired functional material in the form of a hydrogel created by cross-linking an engineered version of calmodulin, a protein which undergoes a conformational change in response to ligand binding (see schematic representation), with a four-armed poly(ethylene glycol) molecule terminated with acrylate groups decreased in volume by 20 % when treated with the ligand trifluoperazine. Multiple cycles of gel swelling and shrinkage were possible.