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Keywords:

  • biomaterials;
  • gels;
  • proteins;
  • supramolecular chemistry
Thumbnail image of graphical abstract

Natural inspiration: A bioinspired functional material in the form of a hydrogel created by cross-linking an engineered version of calmodulin, a protein which undergoes a conformational change in response to ligand binding (see schematic representation), with a four-armed poly(ethylene glycol) molecule terminated with acrylate groups decreased in volume by 20 % when treated with the ligand trifluoperazine. Multiple cycles of gel swelling and shrinkage were possible.