Low catalyst loadings, high enantioselectivities, mild conditions, and fast reaction times are the important features of the first enantioselective organocatalytic electrocyclic reaction: a Nazarov cyclization leading to the synthesis of substituted five-membered rings with a chiral Brønsted acid as a catalyst (see scheme). A further advantage of this method is the possible entry to all four diastereomers of the product.
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