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Keywords:

  • asymmetric catalysis;
  • carboxylic acids;
  • enantioselectivity;
  • hydrogenation;
  • rhodium
Thumbnail image of graphical abstract

It's in the mix: The reaction conditions—catalyst, additive, and solvent—have been optimized for the asymmetric hydrogenation of 3-aryl-3-butenoic acids. The rigid, chiral bisphospholane ligand (Sp,Rc)-DuanPhos is crucial to achieving high enantioselectivity.