Rh-Catalyzed Highly Enantioselective Synthesis of 3-Arylbutanoic Acids

Authors


  • This work was supported by the US National Institutes of Health (GM58832).

Abstract

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It's in the mix: The reaction conditions—catalyst, additive, and solvent—have been optimized for the asymmetric hydrogenation of 3-aryl-3-butenoic acids. The rigid, chiral bisphospholane ligand (Sp,Rc)-DuanPhos is crucial to achieving high enantioselectivity.

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