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Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors


  • R.P.G. and T.M.G. contributed equally to this work. This work was funded by the Biotechnology and Biological Sciences Research Council (BBSRC). G.J.D. holds a Royal Society Wolfson Merit Award. The authors thank Anthony O'Sullivan (Syngenta) for the provision of compound 2 and for useful discussions.


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Strong inhibitions: The inhibition of trehalases, enzymes which hydrolyze the disaccharide trehalose, is a target for novel antibiotic insecticides. The structures (see picture; C black, N blue, O red, S yellow) of a trehalase in complex with validoxylamine A (yellow) and 1-thiatetrazolin (blue) reveal that the inhibitors tightly bind to the enzyme through hydrogen bonds.