Metal-Catalyzed Enantioselective Allylation in Asymmetric Synthesis

Authors

  • Zhan Lu,

    1. Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, China
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  • Shengming Ma Prof.

    1. Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, China
    2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China, Fax: (+86) 216-416-7510
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Abstract

Metal-catalyzed enantioselective allylation, which involves the substitution of allylic metal intermediates with a diverse range of different nucleophiles or SN2′-type allylic substitution, leads to the formation of C[BOND]H, [BOND]C, [BOND]O, [BOND]N, [BOND]S, and other bonds with very high levels of asymmetric induction. The reaction may tolerate a broad range of functional groups and has been applied successfully to the synthesis of many natural products and new chiral compounds.

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