This study was financially supported by BASF-AG. The authors are very grateful to Dr. Thomas Friedrich (BASF) for the purification of OYE3, to Dr. James Hook (UNSW) for his expertise on NMR, and to Martin Bucknall (BMSF, UNSW) for assistance with GC/MS analysis.
Stereospecific Alkyne Reduction: Novel Activity of Old Yellow Enzymes†
Article first published online: 23 MAR 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 18, pages 3316–3318, April 27, 2007
How to Cite
Müller, A., Stürmer, R., Hauer, B. and Rosche, B. (2007), Stereospecific Alkyne Reduction: Novel Activity of Old Yellow Enzymes. Angew. Chem. Int. Ed., 46: 3316–3318. doi: 10.1002/anie.200605179
- Issue published online: 23 APR 2007
- Article first published online: 23 MAR 2007
- Manuscript Received: 22 DEC 2006
- enzyme catalysis;
- green chemistry;
Old enzyme, new trick: An environmentally sustainable alternative for the regio- and stereoselective reduction of the alkyne bond is the biotransformation by “Old Yellow Enzyme” (OYE). This “old” enzyme, first isolated in 1932, catalyzes the trans-selective hydrogenation of the carbon–carbon triple bond under mild conditions.