Iridium-Catalyzed Synthesis of Primary Allylic Amines from Allylic Alcohols: Sulfamic Acid as Ammonia Equivalent


  • This research was supported by the ETH Zürich and the Swiss National Science Foundation. P.M. wishes to thank MEC of Spain for a predoctoral fellowship. The authors acknowledge the English translation of Ref. [26b] by Dr. Nicka Chinkov.


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Two for the price of one: Sulfamic acid serves not only as a nitrogen source but also as an in situ activator of hydroxy groups in the first direct iridium-catalyzed synthesis of primary allylic amines from allylic alcohols (see scheme; cod=cycloocta-1,5-diene). The reaction is catalyzed by a commercially available iridium complex and a phosphoramidite-based bidentate phosphorus–olefin ligand.