Tracking the Chiral Recognition of Adsorbed Dipeptides at the Single-Molecule Level


  • The authors acknowledge Prof. Gero Decher and Dr. Thomas Classen for fruitful discussions and Ignacio Horcas for assistance with WSxM (, the freeware used to process the STM data. G.T. is grateful to the Garlick Scholarship Foundation for financial support. The work of L.C.C. was supported by the Alexander von Humboldt Stiftung and the Deutsche Forschungsgemeinschaft within the Emmy-Noether Programme, and A.D.V. acknowledges support by the EPSRC (UK) and the ESF EUROCORES SONS Programme. CPU time allocation was provided by the HPCx computing facilities through the UKCP consortium (UK), by the Rechenzentrum Garching facilities (Germany) through the German Max Planck Society, and by the HLRS supercomputing facility (Germany) through the HPC-Europa project (RII3-CT-2003-506079, with the support of the European Community, Research Infrastructure Action of the FP6).


original image

Lights, camera, action! The general mechanism of biomolecular recognition introduced by Pauling more than 50 years ago has now been brought to the movie screen (see still frame; D: D-Phe-D-Phe, L: L-Phe-L-Phe). With STM movies, the chiral-recognition process of individual adsorbed di-phenylalanine molecules is followed to illustrate the dynamic induced-fit mechanism at the single-molecule level.