This work was supported by the EPSRC (grant EP/D041007/1 and grant EP/D041082/1 for D.A.R. and S.M.J., respectively).
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“Intelligent” Fingerprinting: Simultaneous Identification of Drug Metabolites and Individuals by Using Antibody-Functionalized Nanoparticles†
Article first published online: 27 APR 2007
DOI: 10.1002/anie.200700217
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Leggett, R., Lee-Smith, Emma E., Jickells, Sue M. and Russell, David A. (2007), “Intelligent” Fingerprinting: Simultaneous Identification of Drug Metabolites and Individuals by Using Antibody-Functionalized Nanoparticles. Angew. Chem. Int. Ed., 46: 4100–4103. doi: 10.1002/anie.200700217
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Publication History
- Issue published online: 16 MAY 2007
- Article first published online: 27 APR 2007
- Manuscript Revised: 26 MAR 2007
- Manuscript Received: 16 JAN 2007
Funded by
- EPSRC. Grant Numbers: EP/D041007/1, EP/D041082/1
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- 14By using the fabrication procedure, it is estimated, based on flocculation assays, that 25–30 protein A molecules are assembled onto each nanoparticle. Although there are four antibody binding sites on each protein A, only two binding sites are accessible at anytime.[13] Therefore, the maximum number of antibodies per gold nanoparticle would be 50–60.
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