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Keywords:

  • asymmetric catalysis;
  • copper;
  • phosphane ligands;
  • reduction;
  • sulfones
Thumbnail image of graphical abstract

Access to a chiral sulfone: Asymmetric conjugate reduction of β,β-disubstituted α,β-unsaturated 2-pyridylsulfones with silanes under CuI/binap catalysis provides chiral sulfones with excellent chemical yields and enantioselectivities (see scheme). These enantioenriched 2-pyridylsulfones are versatile intermediates in the preparation of a wide variety of functionalized chiral compounds. binap=2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl.