This work was supported by the European Commission (Marie Curie Postdoctoral Fellowship to E.R.G.) and by the Conseil Régional d'Aquitaine. We thank Katell Bathany for mass spectroscopy data.
Development and Biological Assessment of Fully Water-Soluble Helical Aromatic Amide Foldamers†
Article first published online: 19 APR 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 22, pages 4081–4084, May 25, 2007
How to Cite
Gillies, Elizabeth R., Deiss, F., Staedel, C., Schmitter, J.-M. and Huc, I. (2007), Development and Biological Assessment of Fully Water-Soluble Helical Aromatic Amide Foldamers. Angew. Chem. Int. Ed., 46: 4081–4084. doi: 10.1002/anie.200700301
- Issue published online: 16 MAY 2007
- Article first published online: 19 APR 2007
- Manuscript Received: 22 JAN 2007
- Conseil Régional d'Aquitaine
- drug delivery;
- helical structures;
- medicinal chemistry;
Abiotic but bioactive: Folding aromatic amide oligomers possessing helical structures very different from those of α-peptides, β-peptides, or peptoids nevertheless show comparable abilities to penetrate into cells, as well as low toxicity and complete resistance to protease degradation. TFA−=trifluoroacetate.