• Please log in or register to access this feature.

Communication

Development and Biological Assessment of Fully Water-Soluble Helical Aromatic Amide Foldamers†

  1. Elizabeth R. Gillies Dr.1,3,
  2. Frédérique Deiss1,
  3. Cathy Staedel Dr.2,
  4. Jean-Marie Schmitter Prof.1,
  5. Ivan Huc Dr.1

Article first published online: 19 APR 2007

DOI: 10.1002/anie.200700301

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 46, Issue 22, pages 4081–4084, May 25, 2007

Additional Information

How to Cite

Gillies, Elizabeth R., Deiss, F., Staedel, C., Schmitter, J.-M. and Huc, I. (2007), Development and Biological Assessment of Fully Water-Soluble Helical Aromatic Amide Foldamers. Angew. Chem. Int. Ed., 46: 4081–4084. doi: 10.1002/anie.200700301

Author Information

  1. 1

    Université Bordeaux 1 – CNRS UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-002-215

  2. 2

    Université Bordeaux Victor Segalen 2, INSERM U869, 146 rue Léo Saignat, 33076 Bordeaux, France

  3. 3

    Current address: Departments of Chemistry and Chemical and Biochemical Engineering, The University of Western Ontario, London N6A 5B7, Canada

  1. †

    This work was supported by the European Commission (Marie Curie Postdoctoral Fellowship to E.R.G.) and by the Conseil Régional d'Aquitaine. We thank Katell Bathany for mass spectroscopy data.

Publication History

  1. Issue published online: 16 MAY 2007
  2. Article first published online: 19 APR 2007
  3. Manuscript Received: 22 JAN 2007

Funded by

  • Conseil Régional d'Aquitaine

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (218K)

Keywords:

  • drug delivery;
  • helical structures;
  • medicinal chemistry;
  • peptidomimetics
Thumbnail image of graphical abstract

Abiotic but bioactive: Folding aromatic amide oligomers possessing helical structures very different from those of α-peptides, β-peptides, or peptoids nevertheless show comparable abilities to penetrate into cells, as well as low toxicity and complete resistance to protease degradation. TFA−=trifluoroacetate.

View Full Article with Supporting Information (HTML) Get PDF (218K)