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Keywords:

  • bioinorganic chemistry;
  • DNA;
  • Hoogsteen pairs;
  • hydrogen bonds;
  • nucleobases
Thumbnail image of graphical abstract

Silver service: Addition of silver(I) to an oligonucleotide comprising 1-deazaadenine and thymine nucleobases leads to the formation of a Hoogsteen-type double helix with specific binding of one metal ion per base pair (see scheme). Each base pair is mediated by one hydrogen bond and by two coordination bonds.