Rapid and Highly Selective Copper-Free Sonogashira Coupling in High-Pressure, High-Temperature Water in a Microfluidic System


  • This research was supported financially by the project for the “Development of Microspace and Nanospace Reaction Environment Technology for Functional Materials” of the New Energy and Industrial Technology Development Organization (NEDO), Japan.


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All in a whirl: A reaction system based on “step-by-step rapid mixing and heating” with high-pressure, high-temperature water has been applied to an extremely efficient Sonogashira coupling (see picture). No organic solvents or ligands for the Pd catalyst were required. R=Me, OMe, NH2, OH, CF3.