A General Approach to Chemo- and Regioselective Cyclotrimerization Reactions


  • We gratefully acknowledge support from the Department of Education (GAANN Fellowship to D.D.Y), the NCSU Faculty Research and Development Fund, and the Donors of the American Chemical Society Petroleum Research Fund. We thank Ramesh S. Senaiar for conducting exploratory solution-phase reactions.


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Microwave-ready heterocycles: Cobalt-catalyzed [2+2+2] cyclotrimerization of nitrile derivatives with diynes anchored to a solid support under microwave irradiation provides a universal approach to pyridine, pyridone, and iminopyridine products. The reaction is completely chemo- and regioselective, and the products are obtained in excellent yield and high purity.