Generous financial support by the MPG and the Fonds der Chemischen Industrie is gratefully acknowledged. We thank Dr. R. Mynott and his team for expert NMR assistance and Umicore AG & Co KG, Hanau, for a gift of noble metal salts.
Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl2-Catalyzed Cycloisomerization Reaction†
Article first published online: 10 MAY 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 25, pages 4760–4763, June 18, 2007
How to Cite
Fürstner, A., Heilmann, Eike K. and Davies, Paul W. (2007), Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl2-Catalyzed Cycloisomerization Reaction. Angew. Chem. Int. Ed., 46: 4760–4763. doi: 10.1002/anie.200700895
- Issue published online: 11 JUN 2007
- Article first published online: 10 MAY 2007
- Manuscript Received: 28 FEB 2007
- Fonds der Chemischen Industrie
- natural products;
Fighting back: A concise route to the pterocarpene derivative erypoegin H, a natural product endowed with considerable activity against a range of methicillin-resistant Staphyllococcus aureus strains and vancomycin-resistant enterococci, has been developed. The key step in the synthesis is a PtCl2-catalyzed carboalkoxylation reaction of an alkyne (see retrosynthesis; Piv=pivaloyl).