Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl2-Catalyzed Cycloisomerization Reaction


  • Generous financial support by the MPG and the Fonds der Chemischen Industrie is gratefully acknowledged. We thank Dr. R. Mynott and his team for expert NMR assistance and Umicore AG & Co KG, Hanau, for a gift of noble metal salts.


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Fighting back: A concise route to the pterocarpene derivative erypoegin H, a natural product endowed with considerable activity against a range of methicillin-resistant Staphyllococcus aureus strains and vancomycin-resistant enterococci, has been developed. The key step in the synthesis is a PtCl2-catalyzed carboalkoxylation reaction of an alkyne (see retrosynthesis; Piv=pivaloyl).