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Synthetic Vaccines of Tumor-Associated Glycopeptide Antigens by Immune-Compatible Thioether Linkage to Bovine Serum Albumin


  • This work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. S.W. is grateful for a PhD scholarship from the Studienstiftung des Deutschen Volkes.


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Immunologically noninterfering thioether linkages between a carrier protein (bovine serum albumin) and synthetic tumor-associated glycopeptide antigens from MUC1 (as in A) are important prerequisites for the development of synthetic vaccines useful for active immunization. These thioether linkages are formed by photochemically induced addition of thiol to vinyl groups. None of the sensitive structural elements are affected.

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