Hierarchical Self-Assembly of One-Dimensional Streptavidin Bundles as a Collagen Mimetic for the Biomineralization of Calcite


  • This work was supported by the Canton of Neuchâtel and the Swiss National Science Foundation (Grants FN 200021-105192 and 200020-113348). We thank Prof. C. R. Cantor for providing us with the streptavidin gene, A. Ivanova for producing streptavidin, and L. Addadi, F. Seebeck, and E. Verrechia for insightful comments.


original image

Bundle up: The introduction of streptavidin (as a linker) between two FeII(terpyridine–bis-biotin) connectors affords a one-dimensional metal–organic protein framework (MOPF). In the presence of calcium ions and CO2 vapors, these MOPF aggregates form protein bundles that template the biomineralization of calcite.