Communication

Positional Assembly of Enzymes in Polymersome Nanoreactors for Cascade Reactions†

  1. Dennis M. Vriezema Dr.2,
  2. Paula M. L. Garcia Dr.1,3,
  3. Núria Sancho Oltra1,4,
  4. Nikos S. Hatzakis Dr.1,5,
  5. Suzanne M. Kuiper1,
  6. Roeland J. M. Nolte Prof.1,
  7. Alan E. Rowan Prof.1,
  8. Jan C. M. van Hest Prof.1

Article first published online: 17 AUG 2007

DOI: 10.1002/anie.200701125

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 46, Issue 39, pages 7378–7382, October 1, 2007

Additional Information

How to Cite

Vriezema, Dennis M., Garcia, Paula M. L., Sancho Oltra, N., Hatzakis, Nikos S., Kuiper, Suzanne M., Nolte, Roeland J. M., Rowan, Alan E. and van Hest, Jan C. M. (2007), Positional Assembly of Enzymes in Polymersome Nanoreactors for Cascade Reactions. Angew. Chem. Int. Ed., 46: 7378–7382. doi: 10.1002/anie.200701125

Author Information

  1. 1

    Institute for Molecules and Materials, Department of Organic Chemistry, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands, Fax: (+31) 24-365-2929 http://www.science.ru.nl/orgchem

  2. 2

    Encapson B.V. Toernooiveld 100, 6525 EC Nijmegen, The Netherlands

  3. 3

    Current address: Department of Medicinal Chemistry, N.V. Organon, Molenstraat 110, 5342 CC Oss, The Netherlands

  4. 4

    Current address: Department of Synthetic Organic Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands

  5. 5

    Current address: Nano-Science Center, H.C. Ørsted Instituttet, Universitetsparken 5, Bygning D, 2100 Copenhagen, Denmark

  1. †

    We thank Dr. E. Pierson for guidance with the fluorescence microscope and NWO-ACTS and Synthon B.V. for financial support.

Publication History

  1. Issue published online: 20 SEP 2007
  2. Article first published online: 17 AUG 2007
  3. Manuscript Revised: 18 APR 2007
  4. Manuscript Received: 14 MAR 2007

Funded by

  • NWO-ACTS
  • Synthon B.V.

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Keywords:

  • cascade reactions;
  • catalysis;
  • enzymes;
  • polymersomes;
  • supramolecular chemistry
Thumbnail image of graphical abstract

In a good position: Nanoreactors can be constructed by the controlled positioning of glucose oxidase (GOX) and horseradish peroxidase (HRP) within the central water pool and block-copolymer membrane of polymersomes. A one-pot multistep reaction sequence is performed with the nanoreactor in combination with free Candida antarctica lipase B (CALB) in the bulk solution (see picture; ABTS: 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)).

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