This work was supported by BNL LDRD Grant 04-055, DOE Grant 06742, and NIH Grants P41EB002181 and R01RR017545. We thank Y. Zhang, P. I. Freimuth, G. Hu, H. Li, and C. F. Nathan for kindly providing protein samples, and J. S. Wall, M. Simon, B. Lin, and F. Kito for assistance with STEM analysis.
Assembly of Nanoparticle–Protein Binding Complexes: From Monomers to Ordered Arrays†
Article first published online: 30 MAY 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 27, pages 5111–5114, July 2, 2007
How to Cite
Hu, M., Qian, L., Briñas, Raymond P., Lymar, Elena S. and Hainfeld, James F. (2007), Assembly of Nanoparticle–Protein Binding Complexes: From Monomers to Ordered Arrays. Angew. Chem. Int. Ed., 46: 5111–5114. doi: 10.1002/anie.200701180
- Issue published online: 22 JUN 2007
- Article first published online: 30 MAY 2007
- Manuscript Received: 17 MAR 2007
- BNL. Grant Numbers: LDRD Grant 04-055, DOE Grant 06742
- NIH. Grant Numbers: P41EB002181, R01RR017545
- electron microscopy;
- hybrid materials;
Tag it: Well-defined monomers, dimers, trimers, three-dimensional spherical shells, and two-dimensional ordered arrays of genetically engineered proteins were constructed by using functionalized gold nanoparticles. Nanoparticle size, functionality, and protein genetic motif contribute to the unique geometry, precise stoichiometry, given orientation, and high specificity of these nanoparticle–protein hybrid structures.