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Assembly of Nanoparticle–Protein Binding Complexes: From Monomers to Ordered Arrays


  • This work was supported by BNL LDRD Grant 04-055, DOE Grant 06742, and NIH Grants P41EB002181 and R01RR017545. We thank Y. Zhang, P. I. Freimuth, G. Hu, H. Li, and C. F. Nathan for kindly providing protein samples, and J. S. Wall, M. Simon, B. Lin, and F. Kito for assistance with STEM analysis.


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Tag it: Well-defined monomers, dimers, trimers, three-dimensional spherical shells, and two-dimensional ordered arrays of genetically engineered proteins were constructed by using functionalized gold nanoparticles. Nanoparticle size, functionality, and protein genetic motif contribute to the unique geometry, precise stoichiometry, given orientation, and high specificity of these nanoparticle–protein hybrid structures.

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