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A One-Pot Synthesis of Primary Amides from Aldoximes or Aldehydes in Water in the Presence of a Supported Rhodium Catalyst


  • This work was supported by the Core Research for Evolutional Science and Technology (CREST) program of the Japan Science and Technology Agency (JST) and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Science, Sports and Technology of Japan. We are grateful to Ms. M. Kotani (JST) for her help with the experimental work.


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Dehydration/Rehydration in Water: Supported rhodium hydroxide (Rh(OH)x/Al2O3) is an effective heterogeneous catalyst for the synthesis of primary amides from aldoximes and aldehydes in water in a reaction that is entirely free of hazardous and carcinogenic organic solvents (see scheme).