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Pyrrolidinyl-Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents
Article first published online: 17 OCT 2007
DOI: 10.1002/anie.200701342
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 46, Issue 46, pages 8748–8758, November 26, 2007
Additional Information
How to Cite
Galliford, C. and Scheidt, K. (2007), Pyrrolidinyl-Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents. Angewandte Chemie International Edition, 46: 8748–8758. doi: 10.1002/anie.200701342
Publication History
- Issue published online: 16 NOV 2007
- Article first published online: 17 OCT 2007
- Manuscript Received: 27 MAR 2007
Funded by
- Northwestern University
- NSF. Grant Number: CHE 0348979
- Abstract
- Article
- References
- Cited By
Keywords:
- antitumor agents;
- medicinal chemistry;
- natural products;
- spirooxindoles;
- total synthesis
Graphical Abstract
1 % Inspiration, 99 % perspiration: Pyrrolidinyl-spirooxindole units are found in numerous bioactive natural products such as spirotryprostatin A (1). Synthetic advances toward the synthesis of this privileged structure have driven the development of analogue synthesis and programs of medicinal chemistry. The biological evaluation of analogues such as 2 shows great promise.
Abstract
The 3,3′-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.