We thank Sun-Hee Lee for technical assistance involving cell culture and CLSM operation at Postech. Financial support from BK-21 and MOST (National Frontier Research Program administered through KRICT/CBM), and Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan are gratefully acknowledged. T.T. is grateful for a JSPS research fellowship for young scientists. Part of this work (A.J., C.W.) was supported by BBSRC.
Guanidine-Containing Molecular Transporters: Sorbitol-Based Transporters Show High Intracellular Selectivity toward Mitochondria†
Article first published online: 2 JUL 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 31, pages 5880–5884, August 3, 2007
How to Cite
Maiti, Kaustabh K., Lee, W., Takeuchi, T., Watkins, C., Fretz, M., Kim, D.-C., Futaki, S., Jones, A., Kim, K.-T. and Chung, S.-K. (2007), Guanidine-Containing Molecular Transporters: Sorbitol-Based Transporters Show High Intracellular Selectivity toward Mitochondria. Angew. Chem. Int. Ed., 46: 5880–5884. doi: 10.1002/anie.200701346
- Issue published online: 25 JUL 2007
- Article first published online: 2 JUL 2007
- Manuscript Received: 28 MAR 2007
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- bioorganic chemistry;
- drug delivery;
Special delivery: Transporters constructed on a sorbitol scaffold with eight guanidine residues show significant translocation across the cell membrane and the blood–brain barrier and high affinities toward mitochondria in HeLa and KG1a leukemia cells. The picture shows colocalisation of one such transporter (T) with MitoTracker red in KG1a cells (scale bars: 10 μm).