This work was supported in part by Grants-in-Aid for Scientific Research (B), Scientific Research on Priority Areas, “Advanced Molecular Transformations of Carbon Resources”, and the 21st Century COE program, COE for a United Approach to New Materials Science, from the Japan Society for the Promotion of Science and the Ministry of Education, Culture, Sports, Science and Technology, Japan. This research was conducted in part at the Advanced Research Institute of Environmental Material Control Engineering, Katsura-Int'tech Center, Graduate School of Engineering, Kyoto University.
Regio- and Stereoselective Synthesis of Enamides and Dienamides by Ruthenium-Catalyzed Co-Oligomerization of N-Vinylamides with Alkenes or Alkynes†
Article first published online: 25 MAY 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 27, pages 5160–5163, July 2, 2007
How to Cite
Tsujita, H., Ura, Y., Matsuki, S., Wada, K., Mitsudo, T.-a. and Kondo, T. (2007), Regio- and Stereoselective Synthesis of Enamides and Dienamides by Ruthenium-Catalyzed Co-Oligomerization of N-Vinylamides with Alkenes or Alkynes. Angew. Chem. Int. Ed., 46: 5160–5163. doi: 10.1002/anie.200701356
- Issue published online: 22 JUN 2007
- Article first published online: 25 MAY 2007
- Manuscript Received: 29 MAR 2007
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- CH activation;
- homogeneous catalysis;
The zero-valent ruthenium complex (η6-1,3,5-cyclooctatriene)bis(η2-dimethyl fumarate)ruthenium effectively catalyzes the highly selective codimerization of N-vinylamides with alkenes or alkynes and was successfully applied in the cotrimerization of N-vinylamides with ethyl acrylate and ethylene (see scheme). These reactions offer a rapid and atom-economical synthesis of biologically and synthetically important enamides and dienamides.