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A Concise Synthesis of Enantioenriched Fluorinated Carbocycles


  • This work was supported by GSK (Y.L.), the Croucher Foundation (Y.L.), the EPSRC (C.B.), and the SNF (C.B.). We thank Dr. A. Cowley for the X-ray studies and Dr. J. M. Brown and Prof. G. W. J. Fleet for helpful discussions. Frontispiece illustration produced by Dr. K. Harrison (University of Oxford).


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A “reverse” cycloaddition–fluorination strategy has been validated to access enantioenriched fluorinated compounds featuring up to five stereogenic centers, one of which is fluorinated. This highly convergent process features a mild and high-yielding fluorination, for which the sense and level of stereocontrol have been probed.

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