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Review
Chemical Design of Nanoparticle Probes for High-Performance Magnetic Resonance Imaging
Article first published online: 23 JUN 2008
DOI: 10.1002/anie.200701674
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Jun, Y.-w., Lee, J.-H. and Cheon, J. (2008), Chemical Design of Nanoparticle Probes for High-Performance Magnetic Resonance Imaging. Angewandte Chemie International Edition, 47: 5122–5135. doi: 10.1002/anie.200701674
Publication History
- Issue published online: 23 JUN 2008
- Article first published online: 23 JUN 2008
- Manuscript Received: 16 APR 2007
- Abstract
- Article
- References
- Cited By
Keywords:
- magnetic properties;
- magnetic resonance imaging;
- medicinal chemistry;
- nanoparticles;
- nanotechnology
Graphical Abstract
Tailor made: Owing to their unique magnetic properties and being a size comparable to biological functional units, tailored magnetic nanoparticles (MNPs) are increasingly used as medical probes. Their use enables the sensitive and target specific observation of biological events at the molecular and cellular levels.
Abstract
Synthetic magnetic nanoparticles (MNPs) are emerging as versatile probes in biomedical applications, especially in the area of magnetic resonance imaging (MRI). Their size, which is comparable to biological functional units, and their unique magnetic properties allow their utilization as molecular imaging probes. Herein, we present an overview of recent breakthroughs in the development of new synthetic MNP probes with which the sensitive and target-specific observation of biological events at the molecular and cellular levels is possible.