This work was partially supported by the Research Grants Council of Hong Kong (HKU2/05C, 604905, 600504), and HKUST (EHIA). B.X. thanks Dr. P. L. Ho for his suggestions in revising the manuscript.
Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth†
Article first published online: 20 AUG 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 43, pages 8216–8219, November 5, 2007
How to Cite
Yang, Z., Liang, G., Guo, Z., Guo, Z. and Xu, B. (2007), Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth. Angew. Chem. Int. Ed., 46: 8216–8219. doi: 10.1002/anie.200701697
- Issue published online: 26 OCT 2007
- Article first published online: 20 AUG 2007
- Manuscript Revised: 17 JUL 2007
- Manuscript Received: 17 APR 2007
- Research Grants Council of Hong Kong. Grant Numbers: HKU2/05C, 604905, 600504
Control from within: Supramolecular hydrogelation to form nanostructures intracellularly (see picture) has been developed as a new methodology to control the fate of cells. Enzyme-regulated self-assembly of small molecules inside cells could lead to a new paradigm for managing cellular processes, understanding cellular functions, and developing new therapeutics through supramolecular chemistry.