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Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth

Authors

  • Zhimou Yang Dr.,

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China, Fax: (+852) 2358-1594
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  • Gaolin Liang Dr.,

    1. Center of Cancer Research, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China
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  • Zufeng Guo,

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China, Fax: (+852) 2358-1594
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  • Zhihong Guo Prof.,

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China, Fax: (+852) 2358-1594
    2. Center of Cancer Research, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China
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  • Bing Xu Prof.

    1. Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China, Fax: (+852) 2358-1594
    2. Center of Cancer Research, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China
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  • This work was partially supported by the Research Grants Council of Hong Kong (HKU2/05C, 604905, 600504), and HKUST (EHIA). B.X. thanks Dr. P. L. Ho for his suggestions in revising the manuscript.

Abstract

original image

Control from within: Supramolecular hydrogelation to form nanostructures intracellularly (see picture) has been developed as a new methodology to control the fate of cells. Enzyme-regulated self-assembly of small molecules inside cells could lead to a new paradigm for managing cellular processes, understanding cellular functions, and developing new therapeutics through supramolecular chemistry.

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