Enhanced Cooperative Activation Effect in the Hydrolytic Kinetic Resolution of Epoxides on [Co(salen)] Catalysts Confined in Nanocages


  • This work was supported by the National Natural Science Foundation of China (no. 20621063 and 20673113), the National Basic Research Program of China (2003CB615803), the Knowledge Innovation Program of the Chinese Academy of Sciences (DICP K2006B2), and the Programme for Strategic Scientific Alliances between China and the Netherlands (2004CB720607 and NSFC 20520130214). Salen=(R,R)-N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine


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Being cagey: More than two chiral [Co(salen)] catalyst molecules can be confined in one nanocage of SBA-16 by reducing the pore entrance size by silylation. The [Co(salen)]/SBA-16 catalysts with more than two [Co(salen)] complexes in each cage show a significantly enhanced cooperative activation effect and exhibit much higher activity than the homogeneous [Co(salen)] catalyst in the hydrolytic kinetic resolution of epoxides (see scheme).