This research was supported in part by a Grant-in-Aid for Scientific Research (No. 18810009) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, and by a Grant for 21st Century COE Program “Human-Friendly Materials Based on Chemistry” from MEXT. The authors express their appreciation to Dr. A. Hirano for preparation of the TRITC-Mb, and to Dr. D. Y. Furgeson for helpful comments on the preparation of the manuscript. PEG: polyethylene glycol.
Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: A Physiologically Available Oxygen Carrier†
Article first published online: 12 JUL 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 32, pages 6085–6088, August 13, 2007
How to Cite
Kishimura, A., Koide, A., Osada, K., Yamasaki, Y. and Kataoka, K. (2007), Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: A Physiologically Available Oxygen Carrier. Angew. Chem. Int. Ed., 46: 6085–6088. doi: 10.1002/anie.200701776
- Issue published online: 3 AUG 2007
- Article first published online: 12 JUL 2007
- Manuscript Received: 22 APR 2007
- Grant-in-Aid for Scientific Research. Grant Number: 18810009
- Grant for 21st Century COE Program “Human-Friendly Materials Based on Chemistry” from MEXT
- block copolymers;
Take your PIC: Biologically active polyion complex vesicles (PICsomes) with encapsulated myoglobin (Mb) can be prepared by the self-assembly of a pair of oppositely charged block ionomers with polyethylene glycol (PEG) segments (see picture; metMb: metmyoglobin). The loaded Mb maintains reversible oxygenation even in the presence of trypsin.