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Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: A Physiologically Available Oxygen Carrier


  • This research was supported in part by a Grant-in-Aid for Scientific Research (No. 18810009) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, and by a Grant for 21st Century COE Program “Human-Friendly Materials Based on Chemistry” from MEXT. The authors express their appreciation to Dr. A. Hirano for preparation of the TRITC-Mb, and to Dr. D. Y. Furgeson for helpful comments on the preparation of the manuscript. PEG: polyethylene glycol.


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Take your PIC: Biologically active polyion complex vesicles (PICsomes) with encapsulated myoglobin (Mb) can be prepared by the self-assembly of a pair of oppositely charged block ionomers with polyethylene glycol (PEG) segments (see picture; metMb: metmyoglobin). The loaded Mb maintains reversible oxygenation even in the presence of trypsin.

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