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Live-Cell-Permeable Poly(p-phenylene ethynylene)

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  • This work was partially supported by a NIH grant (1R43 GM075516-01)

Abstract

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Light up my life: Stable, bright, conjugated-polymer nanoparticles (CPNs) show promise for fluorescence imaging of live cells. The cell-permeable CPNs are synthesized by a simple solvent exchange, and accumulate exclusively in the cytosol (see picture) without any noticeable inhibition of cell viability.

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