Asymmetric Synthesis of the Phytopathogen (+)-Fomannosin


  • This study was supported by The Ohio State University.


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Three new construction features in one synthesis—for the fused cyclobutene ring, the cyclopentanone, and the functionalized six-membered lactone—characterize the procedure that leads to the natural (+)-enantiomer of the title compound starting with D-glucose. Central to the routing are steps involving organometallic reagents containing ruthenium, osmium, zirconium, and samarium among others.