Communication

Neutral Desorption Sampling of Living Objects for Rapid Analysis by Extractive Electrospray Ionization Mass Spectrometry†

  1. Huanwen Chen Dr.1,2,3,
  2. Shuiping Yang Prof.2,
  3. Arno Wortmann Dr.1,
  4. Renato Zenobi Prof. Dr.1

Article first published online: 4 SEP 2007

DOI: 10.1002/anie.200702200

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 46, Issue 40, pages 7591–7594, October 8, 2007

Additional Information

How to Cite

Chen, H., Yang, S., Wortmann, A. and Zenobi, R. (2007), Neutral Desorption Sampling of Living Objects for Rapid Analysis by Extractive Electrospray Ionization Mass Spectrometry. Angew. Chem. Int. Ed., 46: 7591–7594. doi: 10.1002/anie.200702200

Author Information

  1. 1

    Chemistry Department and Applied Biosciences, ETH Zurich, HCI E 329, 8093 Zürich, Switzerland, Fax: (+41) 44-632-1292

  2. 2

    Applied Chemistry Department, East China Institute of Technology, Fuzhou, 344000, China, Fax: (+86) 794-8258-320

  3. 3

    College of Chemistry, Jilin University, Changchun, 130021, China

  1. †

    This work is partly supported by a grant from NNSFC (No.20505003). H.W.C. sincerely acknowledges support from a Wilheem Simon Fellowship from the CEAC at ETH Zurich.

Publication History

  1. Issue published online: 28 SEP 2007
  2. Article first published online: 4 SEP 2007
  3. Manuscript Revised: 24 JUL 2007
  4. Manuscript Received: 18 MAY 2007

Funded by

  • NNSFC. Grant Number: 20505003

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Keywords:

  • biological samples;
  • high-throughput screening;
  • mass spectrometry;
  • metabolomics;
  • neutral desorption sampling
Thumbnail image of graphical abstract

MS comes to life: A novel method to sample surfaces of biological objects uses a neutral gas beam for in vivo EESI mass spectrometric analysis without sample pretreatment (see picture; QTOF=quadropole time-of-flight). The sampling process results in rapid in vivo analyses with reduced ion suppression and without chemical contamination. This strategy can be used in food quality monitoring, homeland security, metabolomics, and clinical diagnosis.

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