SEARCH

SEARCH BY CITATION

Keywords:

  • biological samples;
  • high-throughput screening;
  • mass spectrometry;
  • metabolomics;
  • neutral desorption sampling
Thumbnail image of graphical abstract

MS comes to life: A novel method to sample surfaces of biological objects uses a neutral gas beam for in vivo EESI mass spectrometric analysis without sample pretreatment (see picture; QTOF=quadropole time-of-flight). The sampling process results in rapid in vivo analyses with reduced ion suppression and without chemical contamination. This strategy can be used in food quality monitoring, homeland security, metabolomics, and clinical diagnosis.