Neutral Desorption Sampling of Living Objects for Rapid Analysis by Extractive Electrospray Ionization Mass Spectrometry

Authors

  • Huanwen Chen Dr.,

    1. Chemistry Department and Applied Biosciences, ETH Zurich, HCI E 329, 8093 Zürich, Switzerland, Fax: (+41) 44-632-1292
    2. Applied Chemistry Department, East China Institute of Technology, Fuzhou, 344000, China, Fax: (+86) 794-8258-320
    3. College of Chemistry, Jilin University, Changchun, 130021, China
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  • Shuiping Yang Prof.,

    1. Applied Chemistry Department, East China Institute of Technology, Fuzhou, 344000, China, Fax: (+86) 794-8258-320
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  • Arno Wortmann Dr.,

    1. Chemistry Department and Applied Biosciences, ETH Zurich, HCI E 329, 8093 Zürich, Switzerland, Fax: (+41) 44-632-1292
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  • Renato Zenobi Prof. Dr.

    1. Chemistry Department and Applied Biosciences, ETH Zurich, HCI E 329, 8093 Zürich, Switzerland, Fax: (+41) 44-632-1292
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  • This work is partly supported by a grant from NNSFC (No.20505003). H.W.C. sincerely acknowledges support from a Wilheem Simon Fellowship from the CEAC at ETH Zurich.

Abstract

original image

MS comes to life: A novel method to sample surfaces of biological objects uses a neutral gas beam for in vivo EESI mass spectrometric analysis without sample pretreatment (see picture; QTOF=quadropole time-of-flight). The sampling process results in rapid in vivo analyses with reduced ion suppression and without chemical contamination. This strategy can be used in food quality monitoring, homeland security, metabolomics, and clinical diagnosis.

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