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Keywords:

  • depsipeptides;
  • hydrogen bonds;
  • molecular dynamics;
  • protein folding;
  • superhelices
Thumbnail image of graphical abstract

The latest twist: The effect of backbone H-bonding on the stability of proteins was studied by experimental techniques and molecular dynamics simulation. The structure of the coiled-coil model peptide examined (see picture) is affected by interactions in the solvent-exposed regions as well as by interhelical hydrophobic interactions.