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Antibacterial and Hemolytic Activities of Pyridinium Polymers as a Function of the Spatial Relationship between the Positive Charge and the Pendant Alkyl Tail


  • This work was supported by the Huck Institutes of the Life Sciences and the Materials Research Institute of the Pennsylvania State University.


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The benefits of separation: For homologous polymers having similar backbone composition and charge/tail ratios, placing the charge and alkyl tail on spatially separated centers results in a higher membrane-disrupting ability, as evident from the increased antibacterial and hemolytic activities. The spatial separation particularly amplifies mammalian cell toxicity (see picture).