This work was carried out in the framework of the National Project “Stereoselezione in Sintesi Organica” supported by MIUR, Rome. Financial support from the Consorzio CINMPIS, Bari, is also gratefully acknowledged.
Organocatalytic Asymmetric α-Selenenylation of Aldehydes†
Article first published online: 6 AUG 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 46, Issue 36, pages 6882–6885, September 10, 2007
How to Cite
Tiecco, M., Carlone, A., Sternativo, S., Marini, F., Bartoli, G. and Melchiorre, P. (2007), Organocatalytic Asymmetric α-Selenenylation of Aldehydes. Angew. Chem. Int. Ed., 46: 6882–6885. doi: 10.1002/anie.200702318
- Issue published online: 4 SEP 2007
- Article first published online: 6 AUG 2007
- Manuscript Received: 25 MAY 2007
- MIUR, Rome
- Consorzio CINMPIS
- asymmetric synthesis;
- synthetic methods
Getting round the (periodic) table: The enamine activation concept has been extended to the asymmetric addition of selenium-based compounds to aldehydes in an organocatalytic transformation that provides high reaction efficiency and stereocontrol (ee values ranging from 95 to 99 %) with readily available chiral secondary amines. The chiral α-seleno aldehydes thus formed can be used as versatile intermediates .