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Dual Catalysis: A Combined Enantioselective Brønsted Acid and Metal-Catalyzed Reaction—Metal Catalysis with Chiral Counterions

Authors

  • Magnus Rueping Prof. Dr.,

    1. Degussa Endowed Professorship, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue Strasse 7, 60438 Frankfurt am Main, Germany, Fax: (+49) 69-798-29248
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  • Andrey P. Antonchick Dr.,

    1. Degussa Endowed Professorship, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue Strasse 7, 60438 Frankfurt am Main, Germany, Fax: (+49) 69-798-29248
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  • Claus Brinkmann Dipl.-Chem.

    1. Degussa Endowed Professorship, Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue Strasse 7, 60438 Frankfurt am Main, Germany, Fax: (+49) 69-798-29248
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  • We gratefully acknowledge Degussa AG and DFG (Schwerpunktprogramm Organokatalyse) for financial support.

Abstract

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Double take: The combination of enantioselective Brønsted acid catalyzed activation and metal-catalyzed alkynylation of α-imino esters under mild reaction conditions leads to amino acids in high yields and with excellent e.r. values (see scheme; PG=protecting group).

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