This work was supported by the integrated project PACE (EU-IST-FET). We thank M. Wüstefeld for automated DNA syntheses and protocol development for trisoligonucleotides.
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Communication
Self-Assembly of a DNA Dodecahedron from 20 Trisoligonucleotides with C3h Linkers†
Article first published online: 28 MAR 2008
DOI: 10.1002/anie.200702682
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Zimmermann, J., Cebulla, M., Mönninghoff, S. and von Kiedrowski, G. (2008), Self-Assembly of a DNA Dodecahedron from 20 Trisoligonucleotides with C3h Linkers. Angewandte Chemie International Edition, 47: 3626–3630. doi: 10.1002/anie.200702682
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Publication History
- Issue published online: 21 APR 2008
- Article first published online: 28 MAR 2008
- Manuscript Revised: 11 FEB 2008
- Manuscript Received: 19 JUN 2007
Funded by
- PACE
Keywords:
- DNA structures;
- nanostructures;
- self-assembly;
- supramolecular chemistry;
- trisoligonucleotides
Graphical Abstract
Can 20 trisoligonucleotides with 20×3 individual sequences be programmed to self-assemble into a DNA dodecahedron? The answer is yes if one starts from a new generation of trisoligonucleotides based on C3h-symmetric linkers with proper flexibility. The resulting dodecahedron has C1 symmetry and may facilitate the construction of multimodular scaffolds in the future.