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Keywords:

  • (+)-fawcettimine;
  • alkaloids;
  • cyclization;
  • gold;
  • total synthesis
Thumbnail image of graphical abstract

An effective combination: With the first asymmetric total synthesis of fawcettimine (1) it has been shown that the use of organocatalytic annulation and gold(I)-catalyzed cyclization reactions provides an effective combination for the synthesis of complex molecules. The absolute configuration of 1 was established through an X-ray structure analysis of its hydrobromide.