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Total Synthesis of (+)-Fawcettimine


  • We gratefully acknowledge the University of California, Berkeley, NIHGMS (R01 GM073932-01), Merck Research Laboratories, Bristol-Myers Squibb, Amgen Inc., DuPont, GlaxoSmithKline, Eli Lilly & Co., Pfizer, AstraZeneca, and Roche for financial support.


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An effective combination: With the first asymmetric total synthesis of fawcettimine (1) it has been shown that the use of organocatalytic annulation and gold(I)-catalyzed cyclization reactions provides an effective combination for the synthesis of complex molecules. The absolute configuration of 1 was established through an X-ray structure analysis of its hydrobromide.