Making Ultrasensitive Weighing Biocompatible by Placing the Sample within a Resonant Cantilever


  • The author is grateful to M. Heilemann, M. Sauer, and H. E. Gaub are thanked for proofreading the manuscript and the Nanosystems Initiative Munich (NIM) is acknowledged for financial support.


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Weighing biomolecules: Resonant cantilevers allow ultrasensitive weighing by detecting changes in the resonant frequency when mass is added to the cantilever. By placing the fluid inside the cantilever, particles can be measured sensitively under biologically relevant conditions and without labeling. Furthermore, cells can be weighed while flowing through the cantilever.